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Diclazepam 1㎎x100Tabs

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Diclazepam 1mg x 100Tabs(EVOLIX)

Diclazepam (Chlorodiazepam) dosage, effects, toxicity, tolerance and legality

Diclazepam

While commonly known as Diclazepam, this analogue of diazepam is also known Chlorodiazepam by people interested in research chemicals. While this drug has a long history, it hasn't seen a lot of adoption, mainly due to lack of human trials. Invented by Leo Sternbach in 1960, as part of his work at Hoffman-La Roche.
It is extremely similar to diazepam in its effects, with one key difference. It is about ten times as strong as diazepam, which prompts users to consume minimal doses in order to feel the effects. Speaking of which, they are quite similar to diazepam presenting hypnotic, sedative, depressant, amnestic, anxiolytic and anticonvulsant properties. These effect have all been recorded in animal trials for the drug.
One has to be careful with this drug, since benzodiazepines like Diclazepam and Diazepam can induce strokes, seizures or even death if the user abruptly discontinues taking them. For this reason it is important to give yourself some time to stop taking the drug if you've been taking it regularly, which will completely eliminate the risk of the previously mentioned side effects.

Chemistry

As a member of the Benzodiazepine class, Diclazepam hosts a fused benzene ring into a diazeptine ring. Two nitrogen constituents are located in the structure of the dizaeptine ring, as well as an oxygen group. Additionally the fused benzene ring has a chlorine group. Looking down, we can clearly see the connection to a 2-chlorinated phenyl ring.
All of the benzopiazeptine drugs, ending in the suffix -azepam, host the oxygen group, but not necessarily the nitrogen groups.

Pharmacology

Through a very efficient bind with the benzodiazepine receptors in the brain, this chemical produces a wide variety of generally calming effects. This bind directly influences the GABA receptors, magnifying their efficiency and effects over the body. Precisely these receptors are hosting the most inhibited receptor sets in the brain, which results in a sedative effect when this drug is introduced into the system.
Benzodiazepines also have an anticonvulsant effects, which seem to be happening due to the chemical binding with sodium channels, rather than the regularly expected benzodiazepine receptors.
Subjective effects

These effects are retrieved from a database of user reports, so they are indeed subjective, self-reported effects which people have described in their explanations of the experience they've had under the influence of Diclazepam. Most likely not all of these effects will be felt at any one time a person takes this drug, as well as effects not listed here may occur with higher doses, so make sure to practice due diligence

Physical effects

The main physical effect of chlorodiazepam is as a sedative, which can prompt users to feel extremely tired and sleep-deprived, like they haven't slept for a couple of days on end. It seems to be directly connected with the strength of the dosage, so one could potentially knock themselves unconscious through a high enough dose of Diclazepam. Other physical effects include a relative loss over motor control depending on dosage, muscle relaxation and potential dizziness. Taking Diclazepam usually results in the user becoming lazy and completely uninterested to participate in activities.

Cognitive effects

Although a sedative, Diclazepam resembles depressants in the way that it affects the cognition of users. Generally it is felt as a strong sense of relaxation or rather sedation, but also one of decreased inhibition, where users reports just saying what's on their mind in conversations. Depending on the dosage, the severity of these effects goes from mild to rather severe.
Chlorodiazepam can cause very severe side effects to appear such as: Amnesia, Emotional suppression, Delusions and Compulsively taking the drug again and again. Other less severe effects are: Suppression of thought, information and analytic processing. There are positive effects as well, beneficial for some people at the right time like the suppression of anxiety and the inducement of dreams for the user.

Paradoxical effects

Sometimes taking a drug results in effects that are so different from what one could expect, due to complications or difficult combinations of chlorodiazepam with other drugs. Such reactions to benzodiazepines include an increased risk for seizures for people suffering from epilepsy. Beyond this, rare effects with a 1% rate of occurrence for the general population are: an increase in anxiety, violence, irritability, as well as an inhibition of control and may even cause suicidal thoughts and behavior.
Generally, people abusing these substances experience higher levels of risk for these paradoxical effects, but also people with mental disorders and patients on a high dose prescription.

Experience reports

People describe that the experience of Diclazepam is different from Diazepam. It's activity is very long-lasting, and it's subtly expressing its effects. They like the fact that it's not hard hitting. Most of the reviews we've seen report a high level of satisfaction, which is associated with the occurrence of the typical benzodiazepine effects that these people expected.

Toxicity and harm potential

Diclazepam has a really low toxicity, but it can be extremely dangerous and possibly deadly if combined with various depressants, including alcohol and opium-based drugs. Practicing due-diligence with these drugs is extremely recommended and we advise not to go out of your way to experiment with combinations.

Tolerance and addiction potential

While Diclazepam it rather safe, when considering toxicity it is not deemed safe for recreational usage, due to the low addiction threshold, which translates to a high chance of both physical and psychological addiction. The body's tolerance to the drug is rather efficient, where a user taking this drug will stop feeling the sedative effects in a matter of a couple of continuous days. Interestingly the tolerance diminishes to normal in between one and two weeks one the user has stopped taking the drug.
Combined with the high addiction potential, this specific situation could potentially motivate a person to compulsively take the drug, day after day seeking the sedative effect, but due to high tolerance, not really feeling them. This is why knowledge is worth gold and it can help keep your health from unnecessary damage.
As we touched upon previously, a lot of unnecessary side-effects can be caused by an abrupt cessation of drug intake, so if you're already taking this drug, have a plan in place to gradually stop taking it, in order to evade unnecessary damage. Not applying this in practice will increase your risks for seizure, chest hypertension and even death. You should also avoid depressants even in the withdrawal period.

Dangerous combinations

Well known to anybody who is using drugs recreationally or to alleviate certain conditions that may impede in their life, is the fact that certain combinations are potentially lethal. While it's safe to make the assumption that this is indeed true, we must accept that some people don't realize this fact. So we are going to say this once again, do not haphazardly combine drugs, or else you're essentially putting your life under unnecessary risk of ending.

Mixing Mentos with Coca-Cola is relatively safe combination when compared to combining benzodiazepines with depressants, such as alcohol or barbiturates, can result in fatal depression of respiratory faculties, leading the user unable to breathe properly. Combinations with depressants can enhance the relaxation and sedation effects, but potentially can induce amnesia or loss of consciousness, due to the severity of relaxation. There is no conceivable and rational scenario, where combining these two types of drugs is justified.
With dissociative drugs like Ketamine, Nitrous Oxide, DXM or PCP, will often lead to a fit of vomiting and potentially unconsciousness, which can lead to fatal suffocation if they both occur at the same time.
Combinations of Diclazepam with Stimulants are also incredibly dangerous, which can lead to vomiting and suffocation, as well as dehydration if water consumption isn't regulated. What happens in these combinations is that the stimulatory effect is much stronger than the sedative effect, but because stimulants generally last shorter than sedatives, a person will get overwhelmed by sedation once the stimulant wears off. This can cause a rapid loss of consciousness, which can expose a person to various physical injuries due to falling, as well as different difficult conditions that may impede on a person's ability to breathe.

Overdose

Overdosing with Diclazepam and Benzodiazepines is a valid issue to consider, which can be onset by a extremely large dose or when combined with various depressant drugs. It's easy to see how dangerous these substances can be for individuals that conduct unreasonable experiments.
Overdoses induced by benzodiazepines are considered a medical emergency, which if not answered in due time, may lead to death, permanent brain injury or long-lasting coma if the person having the overdose is not given immediate medical attention .
Overdoses are being specifically expressed by a few symptoms that you can watch out for. These symptoms are as follows, but not limited to: incomprehensible speech, slow thinking, delusions, confusion, difficulty breathing, unconsciousness or even straight up death. They have to be treated in a medically efficient environment, where proper care can be applied with GABA antagonists or flumazenil, but generally only proper support is the only thing sufferers of an overdose need.

Legal issues

Depending on where you live, Diclazepam is mostly legal and unscheduled. Keep in mind that laws change and any substances can be added to the list of legally regulated substances.
Due to a lack of proper communication channels that most governments unfortunately don't have in place, we find it difficult to come up with a comprehensive list of countries where Diclazepam is regulated.
We know that the UK and the USA are considering this drug completely legal and it isn't scheduled for any form of regulation. On the other side, since 2015, Germany has established laws in place to control this substance and its production, as well as distribution.

Oral Dosage

Light 0.25-1mg

Common 1-1.5mg

Strong 1.5-2mg+

Dangerous Interactions

• Alcohol

o Ethanol ingestion may potentiate the CNS effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Blacking out and memory loss is almost certain.

• GHB/GBL

o The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position.

• Opioids

o Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely

• Tramadol

o Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present. Vomit aspiration a risk when passed out, lay down in recovery position if ingested.

• Metabolism

• Metabolism of this compound has been assessed, revealing diclazepam has an approximate elimination half-life of 42 hours and undergoes N -demethylation to delorazepam , which can be detected in urine for 6 days following administration of the parent compound. Other metabolites detected were lorazepam and lormetazepam which were detectable in urine for 19 and 11 days, respectively, indicating hydroxylation by cytochrome P450 enzymes occurring concurrently with N -demethylation.


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