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MELANOTAN-2 10mg x 1vial + 2ml Injection solvent ample


MELANOTAN-2 10mg x 1vial + 2ml Injection solvent ample


Melanotan 2 has a half life of ~33 hours, this allows you to be very flexible with dosing. Recommended dosages start at 250mcg every day to help your body acclimatize to the peptide and minimize the side effects. You can continue with this dose indefinitely if you are intending to do a low dosage regimen. If you want to dose higher, after 2-4 days, whenever you feel comfortable, up the dose to 500mcg. 500mcg is the most common dosage amount administed by users. You can increase the dose as far as about 1mg but any higher is generally not advised and the users dosing 1mg/dose normally weigh around the 100kg mark.

Suggested Dosing:

Day 1-3

Day 4-6

Day 7 – until you have your desired tan depth
Dose the advised units as per your weight per day up to a maximum of 1mg/day. Anyone can safely dose 1mg/day if they aren't experiencing any bad side effects
** UV exposure during loading level will help to achieve desired color faster**

Maintenance dosing

Once you have reached your desired level of tan then you can enter what is known as the 'maintenance phase'.

Maintenance dosing requires much less frequent dosage than once a day.

Although the level is different for most people it levels out at around 500mcg every 3 or 4 days and a small amount of UV exposure with every or every other dose. This dosage will allow you to maintain your tan through winter without much work.

If you notice at any point you're becoming darker, reduce the dose. If you notice you are getting lighter, add in an extra dose or have some more UV exposure if you can and if you haven't already.

The maintenance dose can be continued indefinitely; however, if chosen to cease dosing for an extended amount of time the user’s sensitivity to the peptide will return, making it easy to reduce pigmentation and then rebuild the tan to the desired level.

Melanotan 2 (otherwise known as MT2) was first synthesized at the University of Arizona. Researches there knew that onc of the best defenses against skin cancer was melanin activated in the skin, a tan. They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body's natural pigmentary system to produce a protective tan prior to UV exposure. The body's naturally occuring hormone MSH causes melanogenesis, a process by which the skin's pigment cells (melanocytes) produce the skin's pigment (melanin). They tested to see if administering this endogenous hormone to the body directly could be an effective method to cause sunless tanning. What they found was that while it appeared to work, natural MSH had too short a half life in the body to be practical as a therapeutic drug. So they decided to find a more potent and stable alternative, one that would be more practical.

After synthesizing and screening hundreds of molecules, the researchers headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7] MSH, that was approimately 1,000 times more potent than the natural MSH. They dubbed this new peptide molecule, "Melanotan" (later Melanotan-1, now know as afamelanotide). The scientists hoped to use these peptides to combat melanoma by stimulating the body's natural pigmentary mechanism to create a tan without first needing exposure to harmful levels of UV radiation. This in turn, they hypothesized, could reduce the potential for skin damage that can eventually lead to skin cancer.

Differences between melanotan and melanotan 2

Melanotan's peptide structure is almost the same as our endogenously produced melanocyte-stimulating hormone. MT is an agonist of the melanocortin-1 receptor (located on melanocyte cells) and when this receptor is triggered it eventually will cause tanning of the skin. MT 1 does not bind well to other receptors.

Melanotan 2 has a shorter sequence of amino acids and also has a slightly different form then melanotan 1. Because of this subtle change, binding at receptors other than the melanocortin-1 receptor is greater than that of Melanotan 1. This receptor binding on other receptors then the melanocortin-1 receptor results in some effects with MT-II usage that the user will not notice in MT1 usage. MT2 also binds to the melanocortin-3 and 4 receptors and this binding will cause increases in sexual arousal.

Which of the two is better?

Some people choose Melanotan 1 (afamelanotide / Scenesse) because afamelanotide causes tanning with less side effects then Melanotan 2. But if you like the spontaneous erections as a side effect and you want more bang for your buck then you should choose melanotan 2. Because the amino-acid sequence is shorter in the case of melanotan2, there are more MT2 peptide chains available compared to MT1 on a mg for mg basis. This means that on a mg for mg basis effectively you need much less in terms of milligram weight of MT II to achieve similar tanning results compared to MT1. So in terms of which MT has the most bang for it's buck most users will choose Melanotan2.

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