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IGF-2 1mg x 1Vial + 2ml Injection solvent ample

$50.00

IGF-2 1mg x 1Vial + 2ml Injection solvent ample

Effective Dose : 60mcg and 120mcg per day, in divided dose.

Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on somatotropin. It is believed to be a major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in adults".

Mount Sinai Researchers Find That Little-Studied Gene May Boost Long-Term Memory and Enhance Cognition

Researchers from Mount Sinai School of Medicine have identified a therapy that may enhance memory and prevent the loss of long-term memory. The research is published in the January 27th issue of Nature.

Led by Cristina Alberini, PhD, Professor of Neuroscience at Mount Sinai, the research team evaluated how a protein called insulin-like growth factor II (IGF-II), a gene expressed during brain development that declines with aging, impacts memory formation and retention.

IGF-II is enriched in the adult brain in several areas, including the hippocampus and cortex, which are known to be important for memory formation. Researchers injected the hippocampus of rats with the protein and found that IGF-II significantly improved long-term memory. The team also found that IGF-II levels increased after learning, and that when that increase was blocked long-lasting memories could not form.

"The implications of these data are far-reaching and give us new clues about how to investigate memory loss and forgetfulness in people with cognitive impairment, like those with Alzheimer°«s disease, stroke, or dementia," said Dr. Alberini.

Prior to this study, very little, if anything, was known about IGF-II in adult brain functions. The researchers tested the impact of injecting IGF-II into rats after "inhibitory avoidance learning," in which the rats learn to avoid an unpleasant experience. They found that compared to control groups, the rats injected with IGF-II had a much stronger memory retention. In addition, the rats maintained an elevated memory for several weeks, while the control group showed diminished memory over the same period of time.

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