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MELANOTAN-1 10mg x 1vial + 2ml Injection solvent ample


MELANOTAN-1 10mg x 1vial + 2ml Injection solvent ample

The loading phase is normally limited to about 7 to 10 days and in this time dosages of 0.5 to 2mg are injected subcutaneously daily. Near the end of this phase one or two tanning sessions are taken so that the tanning process can be kick started. It”Ēs very important to expose all parts of the body to equal amounts of sunlight or ultraviolet radiation. This is to allow for a uniform tan and to limit chances of dark or lighter spots. Results are rapid and care should be taken not to overdo it as that will result in an abnormally dark appearance.

The purpose of the maintenance phase is to prolong the period for which the tanned skin is required. Usually a dose of 0.5mg is taken twice per week. This might be altered depending on how the person reacts. If the tan is getting lighter the dosage might be increased or the period between injections shortened. If the tan is getting to dark the dosage can be lowered or the injection frequency decreased.

Melanotan 2 (otherwise known as MT2) was first synthesized at the University of Arizona. Researches there knew that onc of the best defenses against skin cancer was melanin activated in the skin, a tan. They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body's natural pigmentary system to produce a protective tan prior to UV exposure. The body's naturally occuring hormone MSH causes melanogenesis, a process by which the skin's pigment cells (melanocytes) produce the skin's pigment (melanin). They tested to see if administering this endogenous hormone to the body directly could be an effective method to cause sunless tanning. What they found was that while it appeared to work, natural MSH had too short a half life in the body to be practical as a therapeutic drug. So they decided to find a more potent and stable alternative, one that would be more practical.

After synthesizing and screening hundreds of molecules, the researchers headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7] MSH, that was approimately 1,000 times more potent than the natural MSH. They dubbed this new peptide molecule, "Melanotan" (later Melanotan-1, now know as afamelanotide). The scientists hoped to use these peptides to combat melanoma by stimulating the body's natural pigmentary mechanism to create a tan without first needing exposure to harmful levels of UV radiation. This in turn, they hypothesized, could reduce the potential for skin damage that can eventually lead to skin cancer.

Differences between melanotan and melanotan 2

Melanotan's peptide structure is almost the same as our endogenously produced melanocyte-stimulating hormone. MT is an agonist of the melanocortin-1 receptor (located on melanocyte cells) and when this receptor is triggered it eventually will cause tanning of the skin. MT 1 does not bind well to other receptors.

Melanotan 2 has a shorter sequence of amino acids and also has a slightly different form then melanotan 1. Because of this subtle change, binding at receptors other than the melanocortin-1 receptor is greater than that of Melanotan 1. This receptor binding on other receptors then the melanocortin-1 receptor results in some effects with MT-II usage that the user will not notice in MT1 usage. MT2 also binds to the melanocortin-3 and 4 receptors and this binding will cause increases in sexual arousal.

Which of the two is better?

Some people choose Melanotan 1 (afamelanotide / Scenesse) because afamelanotide causes tanning with less side effects then Melanotan 2. But if you like the spontaneous erections as a side effect and you want more bang for your buck then you should choose melanotan 2. Because the amino-acid sequence is shorter in the case of melanotan2, there are more MT2 peptide chains available compared to MT1 on a mg for mg basis. This means that on a mg for mg basis effectively you need much less in terms of milligram weight of MT II to achieve similar tanning results compared to MT1. So in terms of which MT has the most bang for it's buck most users will choose Melanotan2.

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