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GW-501516 (Cardarine) 10mg x 100tabs

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GW-501516 (Cardarine) 10mg x 100tabs

GW 501516(Cardarine) 

Cardarine is a chemical with many purported health benefits. It can protect the brain and heart and improve muscle growth. However, it also has its negative effects. Read more below to learn about this chemical.

CONTENTS

• Introduction
• Health Benefits of Cardarine/GW501516
• 1) Cardarine Protects the Brain
• 2) Cardarine Benefits the Heart
• 3) Cardarine Increases Metabolism and Prevents Obesity
• 4) Cardarine Protects the Kidneys
• 5) Cardarine Helps the Immune System
• 6) Cardarine Protects Against Liver Damage
• 7) Cardarine Improves Muscle Growth and Stamina
• 8) Cardarine May Help Heal Skin Diseases
• 9) Cardarine May Improve Blood Flow and Wound Healing
• 10) Cardarine Has Antioxidant and Anti-inflammatory Potential
• Potential Risks/Side Effects
• Dosage
Introduction

GW501516 is a chemical that binds to and activates the peroxisome proliferator activator receptor delta (PPAR delta). PPARẟ is a transcription factor, which is a protein that increases the expression of many genes.
The activation of PPARẟ has significant implication in improving cardiovascular health, metabolism, and as an anti-inflammatory agent. However, there are some negative effects to GW as well.

Health Benefits of Cardarine/GW501516

1) Cardarine Protects the Brain

In animals, GW 501516 protects brain vessels when they are under oxidative stress .

Activation of PPARẟ by GW 501516 could drive the development of nerve cells .

Additionally, it prevents blood vessel dysfunction, especially in brain vessels.

2) Cardarine Benefits the Heart

GW 501516 prevents oxidative damage in the heart.

It decreases the risk and severity of atherosclerosis (plaque buildup in the arteries) through a number of mechanisms. GW 501516 increased levels of nitric oxide, which protects against atherosclerosis .

It also reduces lesions and inflammation associated with atherosclerosis in mice .

GW 501516 increases VEGF production from human blood vessel cells, which triggers cell and blood vessel formation .

GW 501516 results in an increase of HDL cholesterol and a decrease in triglycerides in animal studies, potentially decreasing the risk of cardiovascular disease in patients .

3) Cardarine Increases Metabolism and Prevents Obesity

GW 501516 activates PPARẟ, which may increase the breakdown of fatty acids and increase energy expenditure in muscle. This could help treat obesity.

PPARẟ activates the expression of a number of genes involved in reducing cholesterol and increasing energy expenditure.

This treatment could protect against weight gain due to diet.

Also, GW 501516 decreases glucose output by the liver and increases insulin sensitivity in mice .

By driving muscle fiber development in mice, GW 501516 creates a resistance to obesity.

4) Cardarine Protects the Kidneys

In mice, it was shown to inhibit inflammation in kidney cells, and may protect against kidney disease. It does this by lowering MCP-1 expression that is generally increased in such kidney diseases.

5) Cardarine Helps the Immune System

GW 501516 is associated with the suppression of inflammation .
Activated PPARẟ suppresses inflammation in the liver in animals by inhibiting molecules that contribute to inflammatory responses .
GW 501516 can activate PPARẟ which protects specific skin cells from undergoing spontaneous cell death during the wound healing process .
It was also shown to accelerate diabetic wound closure .

6) Cardarine Protects Against Liver Damage

PPARẟ activation by GW 501516 causes the liver to switch its energy source from glucose to fatty acids, thus reducing blood sugar .

In mice, GW 501516 inhibited IL-6, which may help prevent insulin resistance in liver cells.

Short-term use can reverse the liver damage that was due to a high fructose diet.

Also, it can improve nonalcoholic liver disorder in mice .

7) Cardarine Improves Muscle Growth and Stamina

Activation of PPARẟ via GW501516 drives the development of muscle fibers in mice. These muscle fibers are associated with increased physical performance. They were able to run almost twice as long as other mice, indicating improved endurance .

8) Cardarine May Help Heal Skin Diseases

Activation of PPARẟ could improve the inflammation caused by psoriasis (a skin disorder) .

9) Cardarine May Improve Blood Flow and Wound Healing

By activating PPARẟ, Cardarine may increase the synthesis of BH4, which increases nitric oxide production in blood vessels (eNOS) .
Increasing nitric oxide helps improve blood flow.
It also helps during wound healing.

10) Cardarine Has Antioxidant and Anti-inflammatory Potential

Cardarine increases the production of the antioxidant enzymes SOD1 and catalase.

It also inhibits the production of inflammatory molecules such as MCP-1, TNF-alpha, IL-6, and NFκB.

The anti-inflammatory effects can improve fibrosis caused by inflammation in rats .

Potential Risks/Side Effects

GW 501516 increases cell death in liver cells and may cause fibrosis in mice with liver disease.
In animals, there is a potential risk to placental and fetal development with prolonged are large exposure to GW 501516 .

In rats, GW 501516 can cause cancer. There are not enough studies done on humans to show the same effect .

GSK abandoned further development of the drug in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs .

Because GW 501516 has a vast amount of influence in a number of places in the body, you should consider its side effects before pursuing it as a treatment

Dosage

A normal dosage is 2mg/kg per day to selectively activate PPARẟ

A dose of 10 - 20 mg per day is sufficient. Starting at 10 mg per day is recommended to take advantage of body sensitivity to new chemicals. 10 mg per day is intended for endurance, the benefit of loss of fat increases as the dose increases

• For research mice, dosage was given 45 minutes to 1 hour before exercise and results were given.

• GW 501516 was tested in a two-year trial, and there was no reduction or stagnation of the impact. Most people take a rest period of 4 to 6 weeks and run the cycle for 12 to 14 weeks at a time. This is usually consistent with the SARM cycle, but there is no evidence that GW 501516 needs to be off-cycled after such a short time. Since GW 501516 was created for the use of LONG TERM, it should not be used as such.

• Half-life is 16 to 24 hours, 10 mg once daily, 10 mg should be administered once every 10 to 12 hours at higher doses.

・PCT is not necessary, but if toxic anabolic drugs are used against endogenous hormones, it is recommended to use it with PCT.

• Ketone production It is highly recommended to use with meal contents.

• It can be used in conjunction with all kinds of nutrients and arousal benefit agents without harmless reaction.


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