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Epistane Depot 50mg x 10ml


Epistane Depot 50mg / ml 10ml Vial

EffectiveDose:30-60mg/day or 50-120mg/2days
EVOLIX has developed a formulation that leads to resolution and make new products ‘‘M1T Depot‘‘

Anabolic/Androgenic Ratio: 1100:91

1. Epistane: The next generation of hormones: Methylated epitiostanol

I have created this compilation of information in order to help educate people about this chemical and how they can benefit from it.

The first thing that people should know about this, is that it's legal. You can buy it from many supplement companies. I always get it from BN or Nutraplanet (they usually have sales/deals/other good stuff).

I'd also like to say that this should be used just like any steroid. Just because it is sold at supplement stores doesn't mean it's OK to take when you're 135lbs and 18 years old.

How can Epistane be used?

Epistane can be used in many ways. A lot of people run it alone with good results. Our own "getfitdoc" has gained ~15lbs from his latest cycle. It can also be used at the beginning or end of a cycle, just as any other oral is used.

If you are running this with long esters, such as Test e, you could run it at the beginning to help kick-start your cycle, or save it for the last four weeks to get you a boost at the end of your cycle. It will help to shed some water weight before coming off, and getting your estrogen under better control right before post cycle therapy (pct) starts.

No matter what way you use it, the dosing is up to you. My advice is to start low, and see how your body reacts. People have seen results from as low as 20mg per day, but the average dose is 30-40mg/Day. Like any oral, this should not be taken for more than 4-6 weeks.

Sample Stand Alone Cycle:

Week 1: 30mg/day
Week 2: 30mg/day
Week 3: 30mg/day
Week 4: 40mg/day
post cycle therapy (pct)


Week 1: 40mg (start at 10mg first day and move up 10mg each day)
Week 2: 40mg
Week 3: 40mg
Week 4: 40mg
Week 5: 40mg
Week 6: 40mg
post cycle therapy (pct)

Here is an example of two very useful ways to take it on a Test E cycle.

Cycle 1:
Week 1-4: Epistane (See above for dosing)
Week 1-10: Test E
post cycle therapy (pct) 2 weeks after last Test E dose

Cycle 2:
Week 1-10: Test E
Week 9-12: Epistane (see above for dosing)

*The goal here is to start epistane exactly 2 weeks before your LAST Test E injection. Take epistane for 4 weeks, last the 2 weeks that you are not injecting the test is still in your system. Start post cycle therapy (pct) the DAY AFTER your last epistane dosing, which should also be EXACTLY TWO WEEKS AFTER you last Test E dosing.

Do I need to do a post cycle therapy (pct) with Epistane?

YES. Proper post cycle therapy (pct) needs to be ran just like any other cycle.

Epistane Side Effects

Like any other oral compound, some damage will be done to your lipid profile while you're taking this. The advantage that Epistane has over other orals, is that your body can recover from the lipid profile issues very shortly after you stop taking Epistane. To help with this while on cycle, I personally recommend Milk Thistle and NAC, or look into Anabolic Innovations product Cycle Support, and Post Cycle Support to use in post cycle therapy (pct). I believe at BN and NP you can find these in a package and save some money.

Many people who worry about their hairline don't need to worry while on Epistane. It is not a DHT derivative and is NOT hard on your hairline.

What are the benefits?

Most people experience lean muscle gain when taking this. Most people who have used both Anavar and Epistane will say that they have very positive effects. The two are not similar chemically, but very similar with the positive effects it will have on your body.

It also works very well as an anti-estrogen. should NOT be used during post cycle therapy (pct), but people who take it while taking other compounds notice great anti-estrogenic properties (loss of bloating, gyno reduction, acne reduction, etc).

From Iron Addict:

Epistane is one of the newest designer steroids on the market today, and it is gaining attention very quickly. Epistane is actually a methylated version of the controlled substance Epitiostanol (2±,3±-Epithio-5±-androstan-17²-ol), which was created in the 1960's and used as a treatment for breast cancer. Since the only place Epitiostanol is only availabe at this time is in japan, chemists added a methyl group to the compund and the final product was a substance now known as Epistane. Epistane is a sulfur containing steroid which is known to have strong and long lasting anti-estrogenic activity as well as weak androgenic and mytropic activities.

What you can expect?

Since it is designed to be anti-estrogenic you can expect very dry gains from this compound. Epistane has low androgenic to anabolic activity. This meaning that it is much more anabolic then androgenic. Thus making sides very minimal to non existant from this substance. Also one of the great properties of this substance is that it does a great job in keeping the natural suppression of the gonads away. Since it has anti-estrogenic properties it keeps your LH levels elevated and it is also said both through science and human trial that epistane may have the ability to reduce gyno. This is still a widely debated outcome of epistane but is actually showing more and more positive results as it becomes more popular. Even though users will see dry gains on epistane it does not mean that it would be any insufficient for a bulking cycle. In fact it would be beneficial because it would generate lean gains. Through research it is reported that most users who have taken this substance have gained anywhere from 5-12 lbs in a 3-5 week cycle. Now in my opinion epistane would be better in a cutting cycle to keep the body dry while preserving and potentially add more lean muscle tissue.

People also experience a libido increase. Granted if you are stacking this with other compounds it is not guaranteed. The parent compound of Epistane is epitiostanol. This drug is used in japan as a libido increaser. Here is a study on the parent compound epitiostanol.

[A case of advanced breast cancer successfully tre...[Gan To Kagaku Ryoho. 1988] - PubMed Result

A patient with stage IV advanced breast cancer with multiple metastasis (bones of the whole body, lungs) were treated by ovariectomy, administration of an non-steroidal antiestrogen (tamoxifen) and mild chemotherapeutic drugs, with favorable results. After four years, however, the patient had a relapse of the cancer. A steroidal antiestrogen (epitiostanol) was then administered with satisfactory results. When a breast cancer relapse occurs in patients once treated successfully with endocrinotherapy, a different form of endocrinotherapy should be tried. There is a possibility that the mechanism of action of Epitiostanol, which is regarded as a steroidal antiestrogen, is different from that of tamoxifen in which an estrogen receptor (ER) system is included.

By methylating epitiostanol, it becomes orally bioavailable, just like every other oral steroid. Hence...Epistane.

Here are some blood results from people who were running epistane while getting bloodwork.

2006 Epi Bloodwork (20-45mg linear ramp):

SuperSoldier & Dr.D

Date: ...1/07.....1/16.....1/26.................1/01.....2/09

AST ......26........32.........41...................24 ........52
ALT ......31........39.........51...................20 ........45
GGT ......09........05.........07...................15 ........21

ALB.......4.0........3.8........3.9............... ..4.5.......4.8
TBIL......1.8........1.1........1.3............... ..0.6.......0.5
DBIL......0.3........0.3........0.2............... ..NA........NA

CHOL.....145.......149.......171.................1 99......208
LDH.......156.......198.......208................. 129......147
HDL........32.........19.........9................ ...30........26

The following is a nice write-up from LakeMountD:

How Epistane Works

Battling Gyno

Estradiol is the strongest form of estrogen in the human body, effecting several organs. Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Epistane works by binding and deactivating the ER so that no estrodiol-elicited effects can be carried out in the cell. In the case of breast tissue is the primary target receptor responsible for growth and proliferation. Epistane binds to the ER and not only disables the receptor from binding to estradiol, it actually puts the cell in an estrogen deprived state, which decreases the cells viability and leads to a decrease in size and eventual cell death. Other SERMs also block the receptor and AI even block the formation of Estradiol from testosterone conversion. However, the effectiveness at the receptor and long term side effects vary. Epistane has been shown to have one of the strongest and longest effects at the binding site, with minimal side effects when compared to other anti-estrogens.

Increasing Lean Body Mass

Epistane also binds to androgen receptors located on skeletal muscle cells and muscle stem cells. This then leads to changes in muscle cell function and protein synthesis. In the case of muscle stem cells, they will actually change and fuse with your active adult skeletal muscles increasing the muscles potential for growth and repair. On the opposing side, the presence of androgens actually decreases the ability of stem cells to form new fat cells. So you now have increased stem cell conversion to muscle cells and decreased stem cell conversion to fat cells, giving you more positive effects out of your nutrition and training.

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